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2019 Single-cell Pediatric Cancer Atlas Grant

Grants to USA, Canada, and International Researchers
for Single-Cell Profiling of Childhood and Adolescent Cancer

Agency Type:

Foundation / Corporation

Funding Source:

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Alex’s Lemonade Stand Foundation (ALSF)

Deadline Date:

09/30/19 11:59 PM ET

Description:

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Grants to USA, Canada, and International faculty at nonprofit research organizations and institutions to gather research data on childhood and adolescent cancer. Funding is intended to create sets of single-cell resolution profiling data. In-kind data lab services and consultations are also available.

Alex’s Lemonade Stand Foundation seeks to create datasets that profile pediatric cancers at a single-cell resolution level. Single-cell profiling can provide insights into the heterogeneity of cells in a tumor and the surrounding tumor microenvironment, as well as variability in the states of cancer cells, all of which can influence the cancer’s response to treatments. The pediatric cancer atlas will be an open resource for discovery, and a primary goal of this effort is to produce data that can be harmonized. The Single-cell Pediatric Cancer Atlas (ScPCA) will fund the profiling of pediatric cancer samples. This award is designed to produce an atlas of gene expression profiles for pediatric cancers of different types and from different organ sites that can be harmonized to allow comparison within and across type and site.

Data sharing is a critical component of the application, and applicants are expected to share the resulting raw and processed data. For more details about this requirement, see https://www.alexslemonade.org/sites/default/files/single-cell_pediatric_cancer_atlas_rfa.pdf#page=5

  • Applications should focus on profiling of childhood and adolescent cancers (ages 0-19). 
  • Applicants should profile samples with the 10X platform for single-cell profiling, unless another sequencing modality is justified for the cancer or tissue type. 
  • Applicants should consider using barcoded antibodies (CITE-seq) to profile cell surface markers if there are markers that are relevant to the tumor type or microenvironment. 
  • Applicants should perform single-cell RNA-sequencing if feasible. If single-nucleus RNA sequencing is the only possibility, it should be scientifically justified. 
  • Applicants are required to perform RNA-sequencing of the bulk tissue from which the single cells are derived. 

In addition to the full requested budget, applicants may elect to use the ALSF Childhood Cancer Data Lab (CCDL) for the quantification step of single-cell and/or bulk gene expression analysis. The CCDL can also be used for the analysis portion of expression analysis, but applicants should first discuss planned applications with the CCDL and request a letter of support so that adequate support will be available. The CCDL is also available for consultations regarding the management and sharing of the research data which is a required element of this award.

GrantWatch ID#:

GrantWatch ID#: 186756

Estimated Size of Grant:

The requested budget should be in proportion to the scope of the proposed project and should be at or under $200k USD in direct costs over one year.

Term of Contract:

Projected Start Date: January-March 2020
Grant Duration: 12 months

Additional Eligibility Criteria:

- Applicants must have an MD, PhD, or MD/PhD or equivalent and be appointed as faculty (or equivalent) at an academic institution.
- Applicants must have a track record of publication and funding productivity that demonstrates that the project can be accomplished by the investigators.
- Applicant institutions may be based in the United States or abroad, and applicants need not be United States citizens. Funds must be granted to nonprofit institutions or organizations.

Restrictions:
- Grant proposals must be focused on single-cell profiling of pediatric cancer samples.
- Indirect costs are not allowed.
- Funds may not be used for research utilizing human embryonic stem cells or non-human primates. Research with human induced pluripotent stem cells is permissible.

Pre-Application Information:

Proposals due: September 30, 2019 by 11:59 PM ET

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Apply online: https://alsfapps.force.com/FGM_Portal__CommunitySignin

For questions regarding this grant mechanism, reach out to Anna Greene, Director of Science, at 866-333-1213 or by email at a.greene@alexslemonade.org.

For applicants interested in using the CCDL for gene expression analysis, reach out to the CCDL Director, Casey Greene, PhD, at greenescientist@gmail.com to discuss the research plan in more detail.

Alex’s Lemonade Stand Foundation
866-333-1213
Grants@AlexsLemonade.org

URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta   British Columbia   Manitoba   New Brunswick   Newfoundland and Labrador   Northwest Territories   Nova Scotia   Nunavut   Ontario   Prince Edward Island   Quebec   Saskatchewan   Yukon

Israel

International country outside of the USA, Israel and Canada.