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Quality Improvement Solutions for Sustained Epidemic Control Project (QISSEC)

Cooperative Agreements to USA, Canada, and International Nonprofit,
Health, and Faith-Based Organizations for Health Care for Patients with HIV

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Health Resources and Services Administration (HRSA)

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Cooperative agreements to USA, Canada, and International nonprofit organizations, health organizations, and community-based and faith-based organizations for projects to improve health care for patients with HIV. Applicants are advised that required registrations may take up to a month to finalize. The project attempts to improve the effectiveness, efficiency, patient-centeredness, safety, accessibility, and equity of the HIV services in low to middle-income countries (LMIC) as identified by the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) program.

This notice announces the opportunity to apply for funding for the Quality Improvement Solutions for Sustained Epidemic Control Project (QISSEC). The purpose of this project is to facilitate improvements in quality across the HIV care continuum at the site level (defined as the location where persons diagnosed with HIV receive care and treatment) and within the community. 

FY21 PEPFAR priorities recognize quality health services as essential in order to ensure that optimal health outcomes are met on a daily and routine basis. Therefore, all PEPFAR country programs must incorporate explicit quality management (QM) practices, including both quality assurance (QA) and quality improvement (QI) activities into service delivery and partner management. Focused on building the capacity of countries to sustain and spread QI methodologies, improve documentation of efforts, and continuously enhance staff knowledge, QISSEC strives to impact the delivery of quality HIV services, improve health outcomes, and support HIV/AIDS epidemic control. This Notice of Funding Opportunity (NOFO) will fund two cooperative agreements in support of the PEPFAR focus on the management of evidence-informed interventions for scale-up and spread. The successful applicants will facilitate solutions for long-term change management approaches and sustainability of QA and QI activity.

The QISSEC shall focus on developing innovative strategies to improve the delivery of HIV quality care and treatment for use by facilities that serve the most vulnerable individuals in PEPFAR-supported LMICs. Using quality improvement methodologies, tools, and techniques, the project will identify gaps in service delivery, and develop culturally and medically appropriate, sustainable interventions targeted to PEPFAR- identified vulnerable and key populations.

Over 18 years PEPFAR has evolved to a complex and high impact program, with mature stakeholders and partners showing that epidemic control is indeed possible. It is in this context that HRSA is renewing its commitment to PEPFAR and specifically seeking to fill gaps as well as to bring targeted and innovative solutions to the remaining barriers to epidemic control around the globe. The PEPFAR 2021 Country Operational Plan Guidance for all PEPFAR Countries  suggests all PEPFAR country programs must incorporate explicit quality management practices, including both QA and QI activities, into service delivery and partner management.

GrantWatch ID#:

GrantWatch ID#: 194942

Number of Grants:

This NOFO will fund two cooperative agreements.

Estimated Size of Grant:

Up to $20,000,000 per year subject to the availability of appropriated funds

Term of Contract:

The period of performance is September 30, 2021 through September 29, 2026.

Additional Eligibility Criteria:

Eligible applicants include domestic or foreign public or non-profit private entities, including schools of medicine, nursing, public health, management and public administration, and academic health centers, community-based organizations, faith- based organizations, and consortia consisting of such eligible organizations.

NOTE: Multiple applications from an organization are not allowable

Pre-proposal Conference:

HRSA has scheduled the following technical assistance:
- Date: Friday, March 19, 2021
- Time: 1:00 PM – 2:30 PM EST
- Adobe Connect URL Weblink:
- Call-In Number: Dial-in: Conference Call 888-730-9136 for all callers (U.S. and international)
- Participant passcode 5686097 (U.S. and international)

The webinar will be recorded and should be available for viewing by March 31, 2021. The location of the recording and frequently asked questions (FAQ’s) will be discussed during the webinar.

Pre-Application Information:

Application Due Date: May 7, 2021

Ensure your and registrations and passwords are current immediately! HRSA will not approve deadline extensions for lack of registration. Registration in all systems, including and, may take up to 1 month to complete.

Cost Sharing/Match Required: No

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Pre-Application Webinar:

Contact Information:

Before starting your grant application, please review the funding source's website listed below for updates/changes/addendums/conferences/LOIs.

Direct questions to:
Tracey Gantt, MSN, RN, PHNA-BC
Nurse Consultant, OGH/OA/HRSA
Office of the Administrator
Telephone: (301) 443-1219

CFDA Number:


URL for Full Text (RFP):

Geographic Focus:

USA: Alabama;   Alaska;   Arizona;   Arkansas;   California;   Colorado;   Connecticut;   Delaware;   Florida;   Georgia;   Hawaii;   Idaho;   Illinois;   Indiana;   Iowa;   Kansas;   Kentucky;   Louisiana;   Maine;   Maryland;   Massachusetts;   Michigan;   Minnesota;   Mississippi;   Missouri;   Montana;   Nebraska;   Nevada;   New Hampshire;   New Jersey;   New Mexico;   New York City;   New York;   North Carolina;   North Dakota;   Ohio;   Oklahoma;   Oregon;   Pennsylvania;   Rhode Island;   South Carolina;   South Dakota;   Tennessee;   Texas;   Utah;   Vermont;   Virginia;   Washington, DC;   Washington;   West Virginia;   Wisconsin;   Wyoming

USA Territories: American Samoa (USA)   Guam (USA)   Puerto Rico (USA)   Virgin Islands (USA)   Northern Mariana Islands (USA)

USA Compact Free Associations: The Federated States of Micronesia (USA)   Marshall Islands (USA)   Republic of Palau (USA)

Canada: Alberta;   British Columbia;   Manitoba;   New Brunswick;   Newfoundland and Labrador;   Northwest Territories;   Nova Scotia;   Nunavut;   Ontario;   Prince Edward Island;   Quebec;   Saskatchewan;   Yukon;


International country outside of the USA, Israel and Canada.

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